Pharmacokinetic Parameters – To log transform or not to log transform
A proper analysis of pharmacokinetic (PK) data can have incredible implications. Something to think about is how the data should be prepared prior to any statistical analysis. This brings me to the goal of this post – to log or not to log, that is thy question. The short answer is yes, PK parameters should…
Cutaneous PK
So, in a previous post I spoke about systemic pharmacokinetics (PK) and you might be wondering how in the world cutaneous PK might be different. Well, it is and it isn’t – confusing right?. Systemic PK has been investigated and studied well over 100 years. Hypotheses have been tried and validated to develop the concepts…
The Cutaneous Anatomy
Before we dive into cutaneous pharmacokinetics (PK), methods to quantify API concentrations over time, and develop new concepts, we need to understand the cutaneous anatomy. If you are relatively unfamiliar with cutaneous PK, this will help when I mention specific stratifications, such as the stratum corneum or dermal adipocytes, in future posts. While this will…
My First Publication!
I am super excited that my first publication is in the books! In this paper, we evaluated the local bioavailability from topical dermatological drug products containing metronidazole using dermal microdialysis. This might be a methodology to evaluate cutaneous pharmacokinetics. I don’t want to give away the entire story before you read it so come check…
What is Pharmacokinetics?
For a seemingly simple question, the answer yields enough content to be covered over the course of an entire semester (maybe even two). Don’t worry; you did not accidentally enroll in Professor Ben’s Pharmacokinetics 101 class; there will be no final exam or mid-year review. I know what you’re thinking, how will I try to…
Introduction
Who am I? My name is Benjamin A. Kuzma and I love pharmacokinetics (PK). I recently received my Ph.D. in pharmaceutical sciences in 2020 from Long Island University, right before COVID-19 took over life as we knew it. My first day as a postdoctoral fellow was working from home and doing so for the foreseeable…
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Pharmacokinetics with Ben Kuzma 